Brief Report PLATELETS AND THROMBOPOIESIS Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITP
نویسندگان
چکیده
University, Jinan, China; Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; Department of Clinical Laboratory, and Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, China; and Department of Psychiatry and Neurochemistry,
منابع مشابه
Immune thrombocytopenia: serum cytokine levels in children and adults
BACKGROUND Immune thrombocytopenia (ITP) is an immune-mediated platelet disorder in which autoantibody-coated platelets are removed from the blood by monocytic phagocytes and there is impaired platelet production. There is a delicate balance of specific cytokine levels, which has an important role in the immune system and is known to be deregulated in autoimmune diseases. This study was designe...
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Immune thrombocytopenia (ITP) is an autoantibody-mediated bleeding disorder with both accelerated platelet destruction and impaired platelet production. We and others have described impaired regulatory CD4 CD25hi T cells (Treg) numbers and/or suppressive function in ITP patients. Clinical trials using thrombopoietic agents to stimulate platelet production have shown favorable outcomes in ITP pa...
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